Note: the frequency of the drug’s use for conditions in the cluster is represented by the number in parentheses—higher is more frequent—but the number doesn’t have units and can’t be interpreted beyond “higher means the drug is prescribed more.”
====== Cluster 0 ======
—Most common drugs—
1. Respiratory agents (0.951)
2. Topical agents (0.202)
3. Anti-infectives (0.142)
4. Hormones or hormone modifiers (0.117)
5. Central nervous system agents (0.102)
—Conditions in cluster—
Allergic reactions, subsequent encounter
Respiratory cancers
Chronic obstructive pulmonary disease and bronchiectasis
Asthma
Respiratory signs and symptoms
====== Cluster 1 ======
—Most common drugs—
1. Gastrointestinal agents (0.907)
2. Central nervous system agents (0.336)
3. Anti-infectives (0.133)
4. Metabolic agents (0.123)
—Conditions in cluster—
Diseases of the digestive system
Esophageal disorders
Gastroduodenal ulcer
Gastritis and duodenitis
Other specified and unspecified disorders of stomach and duodenum
Abdominal hernia
Regional enteritis and ulcerative colitis
Other specified and unspecified liver disease
Pancreatic disorders (excluding diabetes)
Noninfectious gastroenteritis
Other specified and unspecified gastrointestinal disorders
Obesity
Neoplasm-related encounters
Complication of other surgical or medical care, injury, subsequent encounter
Congenital malformations, deformations & chromosomal abnormalities
Symptoms, Signs and Abnormal Clinical & Lab Findings, not elsewhere classified (NEC)
Abdominal pain and other digestive/abdomen signs and symptoms
====== Cluster 2 ======
—Most common drugs—
1. Topical agents (0.968)
2. Anti-infectives (0.193)
3. Central nervous system agents (0.127)
—Conditions in cluster—
Hemorrhoids
Diseases of the ear and mastoid process
Other specified and unspecified disorders of the ear
External causes of morbidity
Diseases of the eye and adnexa
Cornea and external disease
Cataract and other lens disorders
Glaucoma
Uveitis and ocular inflammation
Retinal and vitreous conditions
Oculofacial plastics and orbital conditions
Refractive error
Blindness and vision defects
Other specified eye disorders
Encounter for observation and examination for conditions ruled out (excludes infectious disease, neoplasm, mental disorders)
Fungal infections
Allergic reactions
Superficial injury; contusion, subsequent encounter
Skin cancers – melanoma
Skin cancers – basal cell carcinoma
Skin cancers – squamous cell carcinoma
Skin cancers – all other types
Neoplasms of unspecified nature or uncertain behavior
Other specified and unspecified upper respiratory disease
Diseases of the skin and subcutaneous tissue
Other specified inflammatory condition of skin
Other specified and unspecified skin disorders
Skin/Subcutaneous signs and symptoms
====== Cluster 3 ======
—Most common drugs—
1. Central nervous system agents (0.744)
2. Anti-infectives (0.467)
3. Hormones or hormone modifiers (0.333)
4. Topical agents (0.187)
5. Nutritional products (0.178)
6. Antineoplastics (0.133)
—Conditions in cluster—
Disease of Blood and Disorders Involving Immune Mechanism
Other specified diseases of veins and lymphatics
Dental Diseases
Intestinal infection
Biliary tract disease
Hearing loss
Factors influencing health status & contact w/ health services
Implant, device or graft related encounter
Other aftercare encounter
Medical examination/evaluation
Acquired absence of limb or organ
Diseases of the genitourinary system
Nonmalignant breast conditions
Benign ovarian cyst
Injury, poisoning & certain other consequences of external causes
Fracture of the upper limb, subsequent encounter
Toxic effects, subsequent encounter
Other unspecified injuries, subsequent encounter
Diseases of the musculoskeletal system and connective tissue
Rheumatoid arthritis and related disease
Osteoarthritis
Other specified joint disorders
Tendon and synovial disorders
Systemic lupus erythematosus and connective tissue disorders
Neoplasms
Gastrointestinal cancers – colorectal
Leukemia – all other types
Benign neoplasms
Uncomplicated pregnancy, delivery or puerperium
Diseases of the respiratory system
Acute and chronic tonsillitis
Acute bronchitis
Other specified and unspecified lower respiratory disease
Fever
Malaise and fatigue
====== Cluster 4 ======
—Most common drugs—
1. Metabolic agents (0.979)
2. Nutritional products (0.141)
3. Central nervous system agents (0.112)
—Conditions in cluster—
Diabetes mellitus without complication
Disorders of lipid metabolism
Other specified and unspecified nutritional and metabolic disorders
Osteoporosis
Other specified bone disease and musculoskeletal deformities
Gout
Abnormal findings without diagnosis
====== Cluster 5 ======
—Most common drugs—
1. Cardiovascular agents (0.908)
2. Coagulation modifiers (0.251)
3. Metabolic agents (0.237)
4. Central nervous system agents (0.197)
—Conditions in cluster—
Diseases of the Circulatory System
Endocarditis and endocardial disease
Essential hypertension
Acute myocardial infarction
Coronary atherosclerosis and other heart disease
Nonspecific chest pain
Other and ill-defined heart disease
Cardiac dysrhythmias
Heart failure
Peripheral and visceral vascular disease
Hypotension
Other specified and unspecified circulatory disease
Acute and unspecified renal failure
Chronic kidney disease
Other specified and unspecified diseases of kidney and ureters
Erectile dysfunction
Circulatory signs and symptoms
Other general signs and symptoms
====== Cluster 6 ======
—Most common drugs—
1. Genitourinary tract agents (0.93)
2. Hormones or hormone modifiers (0.248)
3. Central nervous system agents (0.179)
4. Cardiovascular agents (0.15)
5. Anti-infectives (0.103)
—Conditions in cluster—
Calculus of urinary tract
Other specified and unspecified diseases of bladder and urethra
Urinary incontinence
Hyperplasia of prostate
Other specified male genital disorders
Male reproductive system cancers – prostate
Urinary system cancers – bladder
Genitourinary signs and symptoms
====== Cluster 7 ======
—Most common drugs—
1. Central nervous system agents (0.998)
—Conditions in cluster—
Fracture of the spine and back, subsequent encounter
Fracture of lower limb (except hip), subsequent encounter
Sprains and strains, subsequent encounter
Acquired foot deformities
Scoliosis and other postural dorsopathic deformities
Other nervous system disorders (often hereditary or degenerative)
Epilepsy; convulsions
Liveborn
Pregnancy, childbirth, and the puerperium
Nausea and vomiting
====== Cluster 8 ======
—Most common drugs—
1. Central nervous system agents (0.904)
2. Psychotherapeutic agents (0.414)
—Conditions in cluster—
Diabetes mellitus with complication
Other specified encounters and counseling
Traumatic brain injury (TBI); concussion, subsequent encounter
Mental, behavioral, and neurodevelopmental disorders
Schizophrenia spectrum and other psychotic disorders
Depressive disorders
Bipolar and related disorders
Other specified and unspecified mood disorders
Anxiety and fear-related disorders
Trauma- and stressor-related disorders
Miscellaneous mental and behavioral disorders/conditions
Neurodevelopmental disorders
Other specified substance-related disorders
Musculoskeletal pain, not low back pain
Spondylopathies/spondyloarthropathy (including infective)
Other specified connective tissue disease
Muscle disorders
Low back pain
Diseases of the nervous system
Parkinson`s disease
Headache; including migraine
Neurocognitive disorders
Polyneuropathies
Sleep wake disorders
Nerve and nerve root disorders
Nervous system pain and pain syndromes
Other nervous system disorders (neither hereditary nor degenerative)
Symptoms of mental and substance use conditions
Nervous system signs and symptoms
General sensation/perception signs and symptoms
====== Cluster 9 ======
—Most common drugs—
1. Anti-infectives (0.983)
2. Topical agents (0.119)
—Conditions in cluster—
Any dental condition including traumatic injury
Diverticulosis and diverticulitis
Otitis media
Encounter for prophylactic measures (excludes immunization)
Exposure, encounters, screening or contact with infectious disease
Socioeconomic/psychosocial factors
Nephritis; nephrosis; renal sclerosis
Urinary tract infections
Inflammatory diseases of female pelvic organs
Certain infectious and parasitic diseases
Bacterial infections
Viral infection
Parasitic, other specified and unspecified infections
Coronavirus disease – 2019 (COVID-19)
Open wounds to limbs, subsequent encounter
Sinusitis
Pneumonia (except that caused by tuberculosis)
Influenza
Other specified upper respiratory infections
Skin and subcutaneous tissue infections
====== Cluster 10 ======
—Most common drugs—
1. Nutritional products (0.996)
—Conditions in cluster—
Nutritional anemia
Aplastic anemia
Nutritional deficiencies
Fluid and electrolyte disorders
====== Cluster 11 ======
—Most common drugs—
1. Coagulation modifiers (0.941)
2. Central nervous system agents (0.213)
3. Metabolic agents (0.19)
4. Cardiovascular agents (0.169)
—Conditions in cluster—
Acute pulmonary embolism
Cerebral infarction
Aortic and peripheral arterial embolism or thrombosis
Transient cerebral ischemia
====== Cluster 12 ======
—Most common drugs—
1. Antineoplastics (0.986)
2. Central nervous system agents (0.113)
—Conditions in cluster—
Breast cancer – all other types
====== Cluster 13 ======
—Most common drugs—
1. Hormones or hormone modifiers (0.979)
2. Coagulation modifiers (0.102)
—Conditions in cluster—
Endocrine, nutritional and metabolic diseases
Thyroid disorders
Other specified and unspecified endocrine disorders
Contraceptive and procreative management
Other specified status
Menstrual disorders
Other specified female genital disorders
Endocrine system cancers – thyroid